GRIA1

Across TCGA cell cohorts, GRIA1 mutation is significantly associated with the RNA expression of many other genes, with 403 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIA1-associated genes across cancer lineages are MMP26, CEACAM4, and TUT4. Each is linked with GRIA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIA1-to-partner and partner-to-GRIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by GRIA1-low versus GRIA1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA1→partner) and Y-score (partner→GRIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MMP26 →	+0.040	+5.000	<.001	.005	3	2
OESOPHAGUS	CEACAM4 →	+0.013	+4.906	<.001	.006	3	2
LARGE_INTESTINE	TUT4 →	+0.822	+2.043	.006	.008	3	2
LARGE_INTESTINE	B3GNT4 →	+0.694	+2.829	<.001	<.001	3	2
LARGE_INTESTINE	CTC1 →	+0.706	+2.043	.003	.008	3	2
LARGE_INTESTINE	C6orf136 →	+0.572	+3.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 403 associations by consensus.

MMP26 by GRIA1 expression — KIDNEY

Explore this box plot interactively →