GRHL3

Across TCGA patient cohorts, GRHL3 mutation is significantly associated with the RNA expression of many other genes, with 3,307 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRHL3-associated genes across cancer lineages are CYFIP1, TUBGCP5, and RN7SL745P. Each is linked with GRHL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRHL3-to-partner and partner-to-GRHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYFIP1 grouped by GRHL3-low versus GRHL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL3→partner) and Y-score (partner→GRHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYFIP1 →	+0.526	+2.354	<.001	<.001	3	2
UCEC	TUBGCP5 →	+0.595	+2.839	<.001	<.001	3	2
SKCM	RN7SL745P →	+0.195	+3.741	<.001	<.001	3	2
UCEC	LIN7C →	+0.635	+3.043	<.001	<.001	3	2
UCEC	NUP205 →	+0.709	+2.321	<.001	.001	3	2
UCEC	WASF2 →	+0.483	+2.230	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,307 associations by consensus.

CYFIP1 by GRHL3 expression — UCEC

Explore this box plot interactively →