GRHL3

Across TCGA cell cohorts, GRHL3 mutation is significantly associated with the mutation status of many other genes, with 4,195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRHL3-associated genes across cancer lineages are HIVEP1, PAPLN, and RPS6KA6. Each is linked with GRHL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRHL3-to-partner and partner-to-GRHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIVEP1 grouped by GRHL3-low versus GRHL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL3→partner) and Y-score (partner→GRHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HIVEP1 →	+2.080	+3.906	.003	.003	1	4
LUNG_NSCLC_LUAD	PAPLN →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	RPS6KA6 →	+5.772	+5.772	.002	.002	1	3
SKIN	NR2F6 →	+5.824	+5.824	.002	.002	1	3
SKIN	MAML1 →	+4.824	+5.392	.004	.004	1	3
SKIN	TMC1 →	+4.824	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,195 associations by consensus.

HIVEP1 by GRHL3 expression — LARGE_INTESTINE

Explore this box plot interactively →