GRHL2

Across TCGA patient cohorts, GRHL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,321 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GRHL2-associated proteins across cancer lineages are PPP1R18_S145, RBM39, and ADNP. Each is linked with GRHL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both GRHL2-to-partner and partner-to-GRHL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRHL2 versus PPP1R18_S145 in LSCC, with a Pearson correlation of -0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL2→partner) and Y-score (partner→GRHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP1R18_S145 →	-0.594	-0.774	<.001	<.001	3	6
GBM	RBM39 →	+0.224	+0.303	.001	.006	3	6
LSCC	ADNP →	+0.397	+0.832	<.001	<.001	3	6
LSCC	DHX9 →	+0.297	+0.882	<.001	<.001	3	6
LSCC	ESRP1 →	+0.746	+1.034	<.001	<.001	3	6
UCEC	PLCG2 →	-0.606	-0.970	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,321 associations by consensus.

GRHL2 vs PPP1R18_S145 — LSCC

Explore this scatter interactively →