GRHL2

Across TCGA pan-cancer cohorts, GRHL2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated GRHL2 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GRHL2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GRHL2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and STAD show a favorable association.

KIRC, SKCM, and PAAD are the cancer types where GRHL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.418	0.703	<.001	104	view →
SKCM	OS	Tertile	All	0.693	0.844	<.001	53	view →
PAAD	OS	Quartile	All	0.283	0.618	<.001	36	view →
BLCA	DFS	Tertile	III,IV	0.390	0.163	.004	27	view →
BRCA	OS	Median	All	0.475	0.670	.001	21	view →
STAD	OS	Median	All	0.627	0.534	.014	21	view →
UVM	DFS	Tertile	All	0.362	0.775	.012	18	view →
HNSC	OS	Tertile	All	0.831	0.704	.008	16	view →
COAD	DFS	Tertile	IV	0.318	0.664	.019	13	view →
DLBC	DFS	Median	III,IV	0.196	0.862	.008	12	view →
UCEC	OS	Quartile	III,IV	0.919	0.773	.014	12	view →
SCLC	DFS	Median	All	0.922	0.618	.016	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

GRHL2–KIRC (OS)

Open the KIRC breakdown →