GRHL2

Across TCGA cell cohorts, GRHL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,946 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GRHL2-associated GO terms across cancer lineages are Regulation of inner ear receptor cell differentiation, Regulation of mechanoreceptor differentiation, and Response to indole-3-methanol. Each is linked with GRHL2 in more than 10 cancer types. Because this analysis shows association rather than direction, both GRHL2-to-partner and partner-to-GRHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of inner ear receptor cell differentiation grouped by GRHL2-low versus GRHL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL2→partner) and Y-score (partner→GRHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of inner ear receptor cell differentiation →	+1.510	+2.686	<.001	<.001	3	11
LUNG_SCLC	Regulation of mechanoreceptor differentiation →	+1.510	+2.686	<.001	<.001	3	11
URINARY_TRACT	Response to indole-3-methanol →	+0.217	+3.584	<.001	<.001	3	11
STOMACH	Basolateral protein secretion →	+0.230	+3.331	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Serotonin secretion →	+1.253	+2.651	.001	<.001	3	10
LUNG_NSCLC_LUSC	Serotonin production involved in inflammatory response →	+1.253	+2.651	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,946 associations by consensus.

Regulation of inner ear receptor cell differentiation by GRHL2 expression — LUNG_SCLC

Explore this box plot interactively →