GRHL2

Across TCGA cell cohorts, GRHL2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRHL2-associated genes across cancer lineages are GFRA4, NEUROG1, and OTC. Each is linked with GRHL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRHL2-to-partner and partner-to-GRHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by GRHL2-low versus GRHL2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL2→partner) and Y-score (partner→GRHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GFRA4 →	+0.012	+4.614	<.001	.004	3	1
PANCREAS	NEUROG1 →	+0.032	+4.614	<.001	.004	3	1
PANCREAS	OTC →	+1.353	+4.491	<.001	.003	3	1
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OR11H12 →	+0.130	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GFRA4 by GRHL2 expression — PANCREAS

Explore this box plot interactively →