GRHL1

Across TCGA pan-cancer cohorts, GRHL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GRHL1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GRHL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GRHL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and UCEC are the cancer types where GRHL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.939	0.455	.001	36	view →
HNSC	OS	Median	II,III,IV	0.992	0.935	.028	7	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.520	.040	4	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GRHL1–LSCC (DFS)

Open the LSCC breakdown →