GRHL1

Across TCGA pan-cancer cohorts, GRHL1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRHL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GRHL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRHL1 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

COAD, KIRC, and LUSC are the cancer types where GRHL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRHL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.307	<.001	11	view →
KIRC	Male	II,III,IV	−1.027	<.001	10	view →
LUSC	All	III,IV	+2.986	<.001	9	view →
LUAD	Female	III,IV	+1.473	<.001	9	view →
BLCA	Male	All	+2.433	.009	8	view →
HNSC	All	II,III,IV	−0.865	<.001	8	view →
THCA	Male	All	+0.640	<.001	7	view →
READ	All	II,III,IV	+1.482	<.001	6	view →
UCEC	All	All	+1.372	<.001	6	view →
KICH	All	II,III,IV	−0.656	.010	4	view →
STAD	Male	IV	+1.065	.014	1	view →
CHOL	All	All	+0.596	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GRHL1–COAD

Open the COAD breakdown →