GRHL1

Across TCGA patient cohorts, GRHL1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRHL1-associated genes across cancer lineages are MSH6, TFRC, and Caspase-7-cleavedD198. Each is linked with GRHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRHL1-to-partner and partner-to-GRHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by GRHL1-low versus GRHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL1→partner) and Y-score (partner→GRHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.376	-1.807	<.001	.024	3	2
SKCM	TFRC →	+0.783	+3.321	.004	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.830	+2.756	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.260	-4.295	.001	<.001	3	2
UCEC	4E-BP1 →	+0.259	+3.700	.003	.001	3	2
UCEC	Dvl3 →	+0.126	+1.502	.037	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MSH6 by GRHL1 expression — UCEC

Explore this box plot interactively →