GRHL1

Across TCGA cell cohorts, GRHL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,037 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GRHL1-associated GO terms across cancer lineages are Establishment of epithelial cell apical/basal polarity, Desmosome maintenance, and Bundle of His cell to Purkinje myocyte communication. Each is linked with GRHL1 in more than 10 cancer types. Because this analysis shows association rather than direction, both GRHL1-to-partner and partner-to-GRHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of epithelial cell apical/basal polarity grouped by GRHL1-low versus GRHL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL1→partner) and Y-score (partner→GRHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.252	-1.834	<.001	.002	3	11
LUNG_SCLC	Desmosome maintenance →	+1.325	+1.200	.001	<.001	3	11
LUNG_NSCLC_LUAD	Bundle of His cell to Purkinje myocyte communication →	+0.312	+2.231	<.001	<.001	3	10
URINARY_TRACT	Cellular response to alcohol →	+0.087	+1.950	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Action potential propagation →	-1.054	-1.585	<.001	<.001	3	10
LIVER	Basolateral protein secretion →	+0.246	+1.300	.005	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,037 associations by consensus.

Establishment of epithelial cell apical/basal polarity by GRHL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →