GRHL1

Across TCGA cell cohorts, GRHL1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRHL1-associated genes across cancer lineages are PZP, NPY2R, and TARM1. Each is linked with GRHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRHL1-to-partner and partner-to-GRHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PZP grouped by GRHL1-low versus GRHL1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL1→partner) and Y-score (partner→GRHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PZP →	+0.036	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	NPY2R →	+0.047	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	TARM1 →	+0.016	+4.662	<.001	.005	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MAGEB10 →	+0.072	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SPEM2 →	+0.058	+3.726	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PZP by GRHL1 expression — BLOOD_Myeloma

Explore this box plot interactively →