GREB1L

Across TCGA patient cohorts, GREB1L mutation is significantly associated with the RNA expression of many other genes, with 6,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GREB1L-associated genes across cancer lineages are CCL4, CCL5, and FCGR3A. Each is linked with GREB1L in more than 2 cancer types. Because this analysis shows association rather than direction, both GREB1L-to-partner and partner-to-GREB1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL4 grouped by GREB1L-low versus GREB1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREB1L→partner) and Y-score (partner→GREB1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+1.024	+2.565	<.001	<.001	3	3
UCEC	CCL5 →	+1.224	+1.851	<.001	<.001	3	3
UCEC	FCGR3A →	+1.062	+2.044	<.001	<.001	3	3
COAD	PTMAP4 →	+1.305	+2.026	<.001	.005	3	3
COAD	CLEC5A →	+0.635	+3.348	.006	.004	3	3
UCEC	CD8A →	+1.159	+2.565	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,039 associations by consensus.

CCL4 by GREB1L expression — UCEC

Explore this box plot interactively →