GREB1L

Across TCGA pan-cancer cohorts, GREB1L RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GREB1L data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher GREB1L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GREB1L expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

MESO, UVM, and BRCA are the cancer types where GREB1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.267	0.511	<.001	143	view →
UVM	DFS	Median	All	0.401	0.772	<.001	138	view →
BRCA	OS	Median	All	0.955	0.893	<.001	96	view →
KIRC	DFS	Median	All	0.552	0.695	<.001	82	view →
KICH	DFS	Tertile	III,IV	0.312	1.000	.002	65	view →
HNSC	OS	Quartile	All	0.587	0.742	.001	57	view →
ACC	DFS	Tertile	All	0.500	0.835	<.001	56	view →
LUAD	OS	Quartile	All	0.562	0.771	<.001	51	view →
STAD	DFS	Tertile	All	0.555	0.717	.002	44	view →
LGG	OS	Quartile	All	0.924	0.791	.001	35	view →
CESC	DFS	Tertile	All	0.728	0.871	<.001	30	view →
PAAD	OS	Quartile	All	0.357	0.621	.001	29	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GREB1L–MESO (OS)

Open the MESO breakdown →