GREB1L

Across TCGA patient cohorts, GREB1L mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GREB1L-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and GAPDH. Each is linked with GREB1L in more than 2 cancer types. Because this analysis shows association rather than direction, both GREB1L-to-partner and partner-to-GREB1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GREB1L-low versus GREB1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREB1L→partner) and Y-score (partner→GREB1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.626	+2.341	<.001	<.001	3	3
COAD	eIF4E →	+0.172	+3.334	.017	.005	3	2
COAD	GAPDH →	+0.638	+2.597	.001	.005	3	2
UCEC	MEK1 →	+0.411	+3.247	<.001	<.001	3	2
UCEC	MSH2 →	-0.284	-3.143	<.001	<.001	3	2
COAD	ATM →	-0.519	-2.691	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by GREB1L expression — UCEC

Explore this box plot interactively →