GRB7

Across TCGA patient cohorts, GRB7 protein abundance is significantly associated with the RNA expression of many other genes, with 10,890 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GRB7-associated genes across cancer lineages are ERBB2, PARD6B, and MIEN1. Each is linked with GRB7 in more than 7 cancer types. Because this analysis shows association rather than direction, both GRB7-to-partner and partner-to-GRB7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRB7 versus ERBB2 in BRCA, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB7→partner) and Y-score (partner→GRB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERBB2 →	+2.385	+1.402	<.001	<.001	3	8
UCEC	PARD6B →	+0.670	+0.823	.002	<.001	3	6
HNSC	MIEN1 →	+0.915	+0.715	.003	<.001	3	6
LSCC	TUFT1 →	+0.983	+0.572	.001	<.001	3	5
CCRCC	ERBB3 →	+1.083	+0.275	.002	<.001	3	5
BRCA	PSMD3 →	+1.078	+0.888	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,890 associations by consensus.

GRB7 vs ERBB2 — BRCA

Explore this scatter interactively →