GRB10

Across TCGA patient cohorts, GRB10 protein abundance is significantly associated with the RNA expression of many other genes, with 11,475 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GRB10-associated genes across cancer lineages are C6orf223, CD19, and ESM1. Each is linked with GRB10 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRB10-to-partner and partner-to-GRB10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRB10 versus C6orf223 in CCRCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB10→partner) and Y-score (partner→GRB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C6orf223 →	+1.008	+0.328	.002	.002	3	4
PDAC	CD19 →	-0.663	-0.456	.001	<.001	3	4
CCRCC	ESM1 →	+1.589	+0.550	<.001	<.001	3	4
OV	CTIF →	+0.507	+0.414	.003	.005	3	3
OV	SNCG →	-1.654	-0.375	.006	.007	3	3
UCEC	KDM7A-DT →	+0.894	+0.384	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,475 associations by consensus.

GRB10 vs C6orf223 — CCRCC

Explore this scatter interactively →