GRAMD4

Across TCGA patient cohorts, GRAMD4 mutation is significantly associated with the RNA expression of many other genes, with 2,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD4-associated genes across cancer lineages are SLC2AXP1, RPL31P40, and RNU6-918P. Each is linked with GRAMD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRAMD4-to-partner and partner-to-GRAMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2AXP1 grouped by GRAMD4-low versus GRAMD4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD4→partner) and Y-score (partner→GRAMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC2AXP1 →	+0.039	+4.399	<.001	.008	3	3
UCEC	RPL31P40 →	+0.181	+1.674	.006	<.001	3	3
COAD	RNU6-918P →	+0.212	+4.392	<.001	.006	3	3
UCEC	LACTB →	+0.399	+3.119	<.001	<.001	3	2
UCEC	VPS18 →	+0.351	+2.408	.004	<.001	3	2
UCEC	C1QBP →	+0.411	+2.153	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,074 associations by consensus.

SLC2AXP1 by GRAMD4 expression — LUAD

Explore this box plot interactively →