GRAMD4

Across TCGA cell cohorts, GRAMD4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRAMD4-associated genes across cancer lineages are MYH8, FAM47B, and OR7G2. Each is linked with GRAMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD4-to-partner and partner-to-GRAMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH8 grouped by GRAMD4-low versus GRAMD4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD4→partner) and Y-score (partner→GRAMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYH8 →	+0.022	+4.781	<.001	.003	3	1
BREAST	FAM47B →	+0.012	+4.781	<.001	.003	3	1
BLOOD_Leukemia	OR7G2 →	+0.018	+5.201	.003	.006	3	1
BLOOD_Leukemia	TEX26 →	+0.035	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ARMS2 →	+0.021	+4.922	.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.241	+3.252	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MYH8 by GRAMD4 expression — BREAST

Explore this box plot interactively →