GRAMD1C

Across TCGA patient cohorts, GRAMD1C mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD1C-associated genes across cancer lineages are eIF4E, FoxM1, and p38-MAPK_pT180_Y182. Each is linked with GRAMD1C in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD1C-to-partner and partner-to-GRAMD1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GRAMD1C-low versus GRAMD1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1C→partner) and Y-score (partner→GRAMD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.181	+2.335	.003	.002	3	2
UCEC	FoxM1 →	+0.175	+1.241	.021	.015	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.385	-1.459	.003	.011	3	2
UCEC	PDCD4 →	-0.358	-1.058	.009	.037	3	2
UCEC	STAT3_pY705 →	-0.346	-1.584	<.001	.007	3	2
UCEC	TFRC →	+0.358	+1.280	.022	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4E by GRAMD1C expression — UCEC

Explore this box plot interactively →