GRAMD1C

Across TCGA pan-cancer cohorts, GRAMD1C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GRAMD1C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GRAMD1C RNA is repressed in tumor relative to normal tissue. In most cancer types GRAMD1C is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where GRAMD1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRAMD1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.474	<.001	12	view →
KIRP	Female	II,III,IV	−1.648	<.001	11	view →
HNSC	Male	All	−0.718	<.001	11	view →
COAD	Female	All	−1.268	<.001	10	view →
LIHC	Male	III,IV	−1.431	<.001	8	view →
KICH	Male	All	−1.592	<.001	7	view →
LUAD	Female	II,III,IV	−0.943	<.001	7	view →
BLCA	Female	III,IV	+1.114	.017	6	view →
LUSC	Female	All	−0.853	<.001	6	view →
BRCA	Female	All	−0.502	<.001	4	view →
READ	All	II,III,IV	−0.675	.037	1	view →
ESCA	All	All	−0.673	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GRAMD1C–KIRC

Open the KIRC breakdown →