GRAMD1C

Across TCGA cell cohorts, GRAMD1C mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRAMD1C-associated genes across cancer lineages are LGI1, FAM181A, and FAM71B. Each is linked with GRAMD1C in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD1C-to-partner and partner-to-GRAMD1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by GRAMD1C-low versus GRAMD1C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1C→partner) and Y-score (partner→GRAMD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	FAM181A →	+0.022	+4.969	<.001	.003	3	1
BLOOD_Leukemia	FAM71B →	+0.016	+5.060	<.001	.001	3	1
BLOOD_Leukemia	OR4F15 →	+0.007	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	CLDN34 →	+0.067	+5.569	<.001	.001	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LGI1 by GRAMD1C expression — BLOOD_Leukemia

Explore this box plot interactively →