GRAMD1B

Across TCGA patient cohorts, GRAMD1B mutation is significantly associated with the RNA expression of many other genes, with 6,929 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD1B-associated genes across cancer lineages are MICU1, KIF18A, and SLC25A19. Each is linked with GRAMD1B in more than 3 cancer types. Because this analysis shows association rather than direction, both GRAMD1B-to-partner and partner-to-GRAMD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MICU1 grouped by GRAMD1B-low versus GRAMD1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1B→partner) and Y-score (partner→GRAMD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MICU1 →	+0.279	+3.010	.001	<.001	3	4
SKCM	KIF18A →	+0.826	+3.232	.001	.008	3	3
SKCM	SLC25A19 →	+0.401	+3.826	.008	<.001	3	3
UCEC	PAICS →	+0.609	+1.544	<.001	<.001	3	3
SKCM	PDSS1 →	+0.551	+2.604	.003	.005	3	3
SKCM	SUPV3L1 →	+0.418	+2.719	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,929 associations by consensus.

MICU1 by GRAMD1B expression — UCEC

Explore this box plot interactively →