GRAMD1B

Across TCGA pan-cancer cohorts, GRAMD1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRAMD1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GRAMD1B RNA is repressed in tumor relative to normal tissue. In most cancer types GRAMD1B is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and UCEC are the cancer types where GRAMD1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRAMD1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−2.097	<.001	9	view →
THCA	Male	All	−1.171	<.001	6	view →
UCEC	All	All	−1.002	<.001	6	view →
BRCA	Female	All	−0.245	<.001	6	view →
LIHC	All	II,III,IV	+0.985	<.001	5	view →
BLCA	Male	All	+0.429	.001	5	view →
LUAD	All	II,III,IV	+0.778	.026	4	view →
CHOL	All	All	+2.803	<.001	3	view →
KIRC	Male	All	−0.703	<.001	3	view →
LUSC	Female	II,III,IV	−0.627	.005	3	view →
KICH	Male	II,III,IV	−1.285	.001	2	view →
COAD	Male	II,III,IV	+0.629	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GRAMD1B–KIRP

Open the KIRP breakdown →