GRAMD1B

Across TCGA cell cohorts, GRAMD1B mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRAMD1B-associated genes across cancer lineages are CST9, IFNL3, and REG3G. Each is linked with GRAMD1B in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD1B-to-partner and partner-to-GRAMD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9 grouped by GRAMD1B-low versus GRAMD1B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1B→partner) and Y-score (partner→GRAMD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	IFNL3 →	+0.142	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PROP1 →	+0.022	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	EDDM3B →	+0.807	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CST9 by GRAMD1B expression — BLOOD_Lymphoma

Explore this box plot interactively →