GRAMD1A

Across TCGA patient cohorts, GRAMD1A mutation is significantly associated with the RNA expression of many other genes, with 1,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD1A-associated genes across cancer lineages are RNU4-58P, MIR4765, and RN7SL32P. Each is linked with GRAMD1A in more than 2 cancer types. Because this analysis shows association rather than direction, both GRAMD1A-to-partner and partner-to-GRAMD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by GRAMD1A-low versus GRAMD1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1A→partner) and Y-score (partner→GRAMD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.157	+2.133	.003	.007	3	3
LUAD	MIR4765 →	+0.442	+5.197	<.001	.003	3	3
UCEC	RN7SL32P →	+0.278	+2.101	<.001	.001	3	2
UCEC	RN7SL237P →	+0.197	+1.666	<.001	.006	3	2
LUSC	H3Y1 →	+0.686	+2.785	<.001	.008	3	2
KIRP	MTND3P9 →	+0.259	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,236 associations by consensus.

RNU4-58P by GRAMD1A expression — UCEC

Explore this box plot interactively →