Across TCGA patient cohorts, GPX6 mutation is significantly associated with the RNA expression of many other genes, with 650 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX6-associated genes across cancer lineages are SS18L2P1, RNA5SP412, and ZFYVE19. Each is linked with GPX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX6-to-partner and partner-to-GPX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX6→partner) and Y-score (partner→GPX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SS18L2P1 →	+0.742	+3.373	<.001	.004	3	2
UCEC	RNA5SP412 →	+0.623	+2.452	<.001	.001	3	2
UCEC	ZFYVE19 →	+0.417	+3.483	.004	.002	3	2
UCEC	OIP5 →	+0.706	+2.243	.007	.006	3	2
UCEC	FANCA →	+0.570	+3.343	.003	.005	3	2
UCEC	MRPS18B →	+0.461	+2.233	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 650 associations by consensus.

Exploration

GPX6 survival (RNA) · tumor vs normal (RNA) · all GPX6 data types