Across TCGA pan-cancer cohorts, GPX6 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GPX6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPX6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPX6 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

HNSC, PRAD, and LIHC are the cancer types where GPX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.014	.029	4	view →
PRAD	All	All	−0.115	.006	2	view →
LIHC	All	All	+0.004	.006	2	view →
KIRC	Female	All	+0.013	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: GPX6 RNA expression & survival · all GPX6 data types