Across TCGA patient cohorts, GPX6 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GPX6-associated genes across cancer lineages are p90 RSK, YB-1, and MEK1. Each is linked with GPX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX6-to-partner and partner-to-GPX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX6→partner) and Y-score (partner→GPX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.230	+1.874	.004	.047	3	2
SKCM	YB-1 →	+0.165	+3.000	.035	.034	3	2
UCEC	MEK1 →	+0.384	+2.807	.016	.003	3	1
UCEC	p90 RSK_pT359_S363 →	+0.178	+2.115	.044	.019	3	1
UCEC	PCNA →	+0.202	+2.999	.032	.035	3	1
UCEC	Rad50 →	-0.340	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

GPX6 survival (RNA) · tumor vs normal (RNA) · all GPX6 data types