Across TCGA patient cohorts, GPX5 mutation is significantly associated with the RNA expression of many other genes, with 203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX5-associated genes across cancer lineages are APOOP3, PLEKHG4B, and CPAMD8. Each is linked with GPX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX5-to-partner and partner-to-GPX5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX5→partner) and Y-score (partner→GPX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	APOOP3 →	+0.075	+3.017	.003	.003	3	2
UCEC	PLEKHG4B →	-1.173	-3.574	<.001	.003	3	1
UCEC	CPAMD8 →	-1.539	-3.563	<.001	.003	3	1
UCEC	KALRN →	-0.615	-3.552	<.001	.003	3	1
UCEC	DMKN →	-1.452	-3.435	<.001	.005	3	1
UCEC	MYEOV →	+1.527	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 203 associations by consensus.

Exploration

GPX5 survival (RNA) · tumor vs normal (RNA) · all GPX5 data types