GPX4

Across TCGA patient cohorts, GPX4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,119 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GPX4-associated proteins across cancer lineages are FNDC3A, HID1, and MZB1. Each is linked with GPX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPX4-to-partner and partner-to-GPX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPX4 versus FNDC3A in LUAD, with a Pearson correlation of -0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX4→partner) and Y-score (partner→GPX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FNDC3A →	-0.281	-0.447	.001	.001	3	4
LSCC	HID1 →	-0.495	-0.491	<.001	<.001	3	4
LSCC	MZB1 →	-0.803	-0.570	<.001	<.001	3	4
LSCC	CRELD2 →	-0.535	-0.557	<.001	<.001	3	4
LSCC	RRBP1 →	-0.415	-0.408	<.001	<.001	3	4
UCEC	RBM47 →	+0.344	+0.990	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,119 associations by consensus.

GPX4 vs FNDC3A — LUAD

Explore this scatter interactively →