GPX4

Across TCGA pan-cancer cohorts, GPX4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GPX4 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher GPX4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and THCA show a favorable association.

UCS, UCEC, and UVM are the cancer types where GPX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.135	0.790	.004	90	view →
UCEC	DFS	Tertile	All	0.755	0.443	<.001	84	view →
UVM	DFS	Median	II,III,IV	0.358	0.834	<.001	77	view →
KICH	DFS	Quartile	II,III,IV	0.250	1.000	.003	64	view →
ACC	DFS	Quartile	All	0.202	0.602	.003	41	view →
LAML	DFS	Quartile	All	0.248	0.600	<.001	36	view →
THCA	OS	Tertile	II,III,IV	1.000	0.822	.007	31	view →
COAD	OS	Median	II,III,IV	0.488	0.770	.006	22	view →
CESC	DFS	Tertile	II,III,IV	0.740	0.377	.013	18	view →
READ	OS	Tertile	III,IV	0.539	0.899	.010	16	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	15	view →
PAAD	DFS	Quartile	All	0.585	0.371	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GPX4–UCS (OS)

Open the UCS breakdown →