GPX4

Across TCGA patient cohorts, GPX4 protein abundance is significantly associated with the RNA expression of many other genes, with 15,757 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GPX4-associated genes across cancer lineages are RDM1P3, CBX7, and PGPEP1. Each is linked with GPX4 in more than 5 cancer types. Because this analysis shows association rather than direction, both GPX4-to-partner and partner-to-GPX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPX4 versus RDM1P3 in LUAD, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX4→partner) and Y-score (partner→GPX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RDM1P3 →	+0.947	+0.299	<.001	.001	3	6
OV	CBX7 →	+0.815	+0.448	<.001	<.001	3	6
OV	PGPEP1 →	+0.745	+0.264	.003	.008	3	6
PDAC	NR3C2 →	+0.754	+0.202	<.001	<.001	3	6
CCRCC	ACSM5 →	+0.900	+0.294	<.001	<.001	3	6
GBM	ASPA →	+1.157	+0.251	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,757 associations by consensus.

GPX4 vs RDM1P3 — LUAD

Explore this scatter interactively →