GPX4

Across TCGA patient cohorts, GPX4 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX4-associated genes across cancer lineages are RNU6-1242P, RN7SKP181, and MIR6803. Each is linked with GPX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX4-to-partner and partner-to-GPX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1242P grouped by GPX4-low versus GPX4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX4→partner) and Y-score (partner→GPX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1242P →	+0.948	+5.017	<.001	.009	3	2
HNSC	RN7SKP181 →	+0.179	+5.182	<.001	.007	3	2
UCEC	MIR6803 →	+0.276	+5.478	<.001	<.001	3	2
COAD	RPS29P6 →	+0.716	+5.893	<.001	.002	3	1
COAD	GAPDHP56 →	+0.148	+5.017	.006	.009	3	1
UCEC	RMND1 →	+0.783	+3.202	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

RNU6-1242P by GPX4 expression — COAD

Explore this box plot interactively →