GPX4

Across TCGA cell cohorts, GPX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,189 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPX4-associated GO terms across cancer lineages are DNA recombination, Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway, and Cellular response to iron ion. Each is linked with GPX4 in more than 6 cancer types. Because this analysis shows association rather than direction, both GPX4-to-partner and partner-to-GPX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA recombination grouped by GPX4-low versus GPX4-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX4→partner) and Y-score (partner→GPX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA recombination →	-0.070	-0.660	.002	.001	3	7
LUNG_NSCLC_LUAD	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway →	+0.096	+0.576	.002	.002	3	5
LUNG_SCLC	Cellular response to iron ion →	-0.146	-0.721	.001	<.001	3	5
PANCREAS	Regulation of alternative mRNA splicing, via spliceosome →	-0.063	-0.753	<.001	.003	3	5
LUNG_NSCLC_LUSC	Regulation of nucleocytoplasmic transport →	-0.055	-0.758	.008	<.001	3	5
PANCREAS	Negative regulation of DNA metabolic process →	-0.038	-0.719	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,189 associations by consensus.

DNA recombination by GPX4 expression — PANCREAS

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