Across TCGA patient cohorts, GPX3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX3-associated genes across cancer lineages are Myosin-IIa, p62 Lck ligand, and VHL. Each is linked with GPX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX3-to-partner and partner-to-GPX3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX3→partner) and Y-score (partner→GPX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa →	+0.182	+2.818	.041	.035	3	1
UCEC	p62 Lck ligand →	+0.341	+3.009	.024	.019	3	1
UCEC	VHL →	-0.783	-2.321	.013	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.783	+2.584	.004	.011	3	1
UCEC	MEK1 →	+0.441	+2.321	.009	.034	2	1
UCEC	Caspase-8 →	-0.263	-3.169	.024	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

GPX3 survival (RNA) · tumor vs normal (RNA) · all GPX3 data types