Across TCGA pan-cancer cohorts, GPX3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GPX3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPX3 RNA is repressed in tumor relative to normal tissue. In most cancer types GPX3 is over-expressed in tumor, although a few such as HNSC and BLCA show the opposite, repressed pattern.

HNSC, BLCA, and KIRP are the cancer types where GPX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−2.696	<.001	12	view →
BLCA	Male	III,IV	−3.101	<.001	11	view →
KIRP	All	II,III,IV	−2.649	<.001	11	view →
COAD	Male	All	−2.182	<.001	11	view →
STAD	Female	All	−2.357	<.001	10	view →
LUSC	Female	II,III,IV	−4.308	<.001	9	view →
LUAD	Female	III,IV	−3.010	<.001	9	view →
BRCA	All	III,IV	−3.369	<.001	8	view →
THCA	Male	All	−1.558	<.001	8	view →
KICH	All	II,III,IV	−2.828	<.001	7	view →
CHOL	Male	All	−1.575	<.001	4	view →
READ	Female	All	−3.244	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

Exploration

Same gene, other analysis: GPX3 RNA expression & survival · all GPX3 data types