GPX2

Across TCGA patient cohorts, GPX2 mutation is significantly associated with the RNA expression of many other genes, with 549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX2-associated genes across cancer lineages are TMEM269, RPS29P32, and RN7SL478P. Each is linked with GPX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX2-to-partner and partner-to-GPX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM269 grouped by GPX2-low versus GPX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX2→partner) and Y-score (partner→GPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM269 →	+0.244	+2.617	<.001	.006	3	1
UCEC	RPS29P32 →	+0.491	+2.751	<.001	.002	3	1
UCEC	RN7SL478P →	+0.322	+2.769	<.001	<.001	3	1
UCEC	WDR45BP1 →	+0.625	+3.532	<.001	.002	3	1
UCEC	ASB16-AS1 →	+0.539	+3.467	.001	.002	3	1
UCEC	SMC5-AS1 →	+0.472	+2.595	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 549 associations by consensus.

TMEM269 by GPX2 expression — UCEC

Explore this box plot interactively →