GPT2

Across TCGA patient cohorts, GPT2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,698 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GPT2-associated genes across cancer lineages are ABTB1, FADS2, and DBNDD1. Each is linked with GPT2 in more than 5 cancer types. Because this analysis shows association rather than direction, both GPT2-to-partner and partner-to-GPT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPT2 versus ABTB1 in OV, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT2→partner) and Y-score (partner→GPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ABTB1 →	-0.820	-0.712	<.001	<.001	3	6
BRCA	FADS2 →	+1.853	+0.614	<.001	.002	3	5
OV	DBNDD1 →	+0.853	+0.547	.002	<.001	3	5
LUAD	CBX7 →	-0.551	-0.612	<.001	<.001	3	4
BRCA	N4BP2L1 →	-0.677	-0.593	<.001	.003	3	4
BRCA	C16orf87 →	+0.706	+0.791	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,698 associations by consensus.

GPT2 vs ABTB1 — OV

Explore this scatter interactively →