GPT

Across TCGA patient cohorts, GPT RNA expression is significantly associated with the protein abundance of many other proteins, with 12,483 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPT-associated proteins across cancer lineages are C8orf82, AKAP1_T533, and AKAP1. Each is linked with GPT in more than 5 cancer types. Because this analysis shows association rather than direction, both GPT-to-partner and partner-to-GPT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPT versus C8orf82 in LSCC, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT→partner) and Y-score (partner→GPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C8orf82 →	+0.478	+0.623	<.001	<.001	3	6
LSCC	AKAP1_T533 →	+0.568	+0.615	<.001	<.001	3	6
HNSC	AKAP1 →	+0.351	+0.850	<.001	<.001	3	5
CCRCC	PPP1R18_S224 →	-0.451	-1.650	<.001	<.001	3	5
HNSC	RPRD2 →	+0.357	+0.742	<.001	<.001	3	4
LSCC	SCRIB →	+0.300	+0.520	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,483 associations by consensus.

GPT vs C8orf82 — LSCC

Explore this scatter interactively →