GPT

Across TCGA patient cohorts, GPT protein abundance is significantly associated with the RNA expression of many other genes, with 9,390 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GPT-associated genes across cancer lineages are GPD1, PLSCR4, and IGF2BP3. Each is linked with GPT in more than 4 cancer types. Because this analysis shows association rather than direction, both GPT-to-partner and partner-to-GPT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPT versus GPD1 in BRCA, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT→partner) and Y-score (partner→GPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GPD1 →	+1.886	+0.721	<.001	<.001	3	5
OV	PLSCR4 →	+0.899	+0.447	.001	.004	3	4
GBM	IGF2BP3 →	-1.199	-0.560	<.001	.001	3	4
BRCA	IL33 →	+1.444	+0.857	<.001	.001	3	4
HNSC	MYL3 →	+0.990	+0.621	<.001	<.001	3	4
BRCA	S1PR1 →	+0.963	+0.829	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,390 associations by consensus.

GPT vs GPD1 — BRCA

Explore this scatter interactively →