GPT

Across TCGA patient cohorts, GPT mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPT-associated genes across cancer lineages are IGFBP2, YB-1_pS102, and HER2. Each is linked with GPT in more than 1 cancer types. Because this analysis shows association rather than direction, both GPT-to-partner and partner-to-GPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by GPT-low versus GPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT→partner) and Y-score (partner→GPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.786	-3.169	.012	.019	3	1
UCEC	YB-1_pS102 →	-0.192	-2.459	.032	.020	3	1
UCEC	HER2 →	-0.456	-3.169	.037	.019	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IGFBP2 by GPT expression — UCEC

Explore this box plot interactively →