GPT

Across TCGA cell cohorts, GPT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,526 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPT-associated GO terms across cancer lineages are Cilium movement involved in cell motility, Pre-mRNA catabolic process, and Methylglyoxal metabolic process. Each is linked with GPT in more than 13 cancer types. Because this analysis shows association rather than direction, both GPT-to-partner and partner-to-GPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement involved in cell motility grouped by GPT-low versus GPT-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT→partner) and Y-score (partner→GPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cilium movement involved in cell motility →	-0.091	-0.890	.003	.008	3	14
BONE	Pre-mRNA catabolic process →	+0.199	+1.105	<.001	<.001	3	13
OESOPHAGUS	Methylglyoxal metabolic process →	+0.140	+0.839	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.113	-0.862	.002	.008	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.102	-0.895	.004	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.159	+1.078	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,526 associations by consensus.

Cilium movement involved in cell motility by GPT expression — OESOPHAGUS

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