GPS2

Across TCGA patient cohorts, GPS2 mutation is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPS2-associated genes across cancer lineages are RNU1-46P, MIR4491, and SNRPGP17. Each is linked with GPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPS2-to-partner and partner-to-GPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-46P grouped by GPS2-low versus GPS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPS2→partner) and Y-score (partner→GPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU1-46P →	+1.076	+4.547	<.001	.005	3	2
BRCA	MIR4491 →	+0.793	+5.721	<.001	.003	3	1
UCEC	SNRPGP17 →	+0.268	+2.294	.003	.003	3	1
UCEC	RNU6-6P →	+0.489	+2.075	.002	.007	3	1
UCEC	RNA5SP386 →	+0.317	+2.613	<.001	.007	3	1
UCEC	MIR7702 →	+0.263	+4.475	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

RNU1-46P by GPS2 expression — COAD

Explore this box plot interactively →