GPS2

Across TCGA patient cohorts, GPS2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPS2-associated genes across cancer lineages are Heregulin, ACVRL1, and Myosin-IIa_pS1943. Each is linked with GPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPS2-to-partner and partner-to-GPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by GPS2-low versus GPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPS2→partner) and Y-score (partner→GPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.185	-3.321	.004	.010	3	1
UCEC	ACVRL1 →	-0.207	-2.986	.003	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.302	+2.183	.005	.035	3	1
UCEC	Cyclin-B1 →	+0.894	+3.321	.002	.010	3	1
UCEC	53BP1 →	+0.565	+2.999	.001	.035	3	1
BLCA	JNK2 →	+0.214	+2.820	.021	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Heregulin by GPS2 expression — UCEC

Explore this box plot interactively →