GPRC5D

Across TCGA patient cohorts, GPRC5D mutation is significantly associated with the RNA expression of many other genes, with 721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRC5D-associated genes across cancer lineages are RNU6-709P, RNA5SP410, and RNA5SP417. Each is linked with GPRC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5D-to-partner and partner-to-GPRC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by GPRC5D-low versus GPRC5D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5D→partner) and Y-score (partner→GPRC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-709P →	+0.992	+7.142	<.001	<.001	3	2
UCEC	RNA5SP410 →	+0.596	+2.052	<.001	.009	3	2
UCEC	RNA5SP417 →	+0.537	+2.214	<.001	.009	3	2
BLCA	RNU6-226P →	+0.367	+3.799	<.001	.007	3	1
COAD	TTTY7B →	+0.124	+6.251	<.001	.001	3	1
UCEC	MRPL49 →	+0.526	+3.716	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 721 associations by consensus.

RNU6-709P by GPRC5D expression — COAD

Explore this box plot interactively →