GPRC5D

Across TCGA pan-cancer cohorts, GPRC5D RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GPRC5D data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher GPRC5D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPRC5D expression acts as an unfavorable survival marker, although some lineages such as LUSC and HNSC show a favorable association.

UCS, LUSC, and LIHC are the cancer types where GPRC5D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.254	0.593	<.001	74	view →
LUSC	DFS	Median	II,III,IV	0.693	0.523	.001	63	view →
LIHC	OS	Tertile	All	0.686	0.840	.002	60	view →
BRCA	DFS	Median	All	0.878	0.925	<.001	39	view →
ACC	DFS	Quartile	All	0.137	0.681	.006	35	view →
LGG	OS	Tertile	All	0.379	0.552	<.001	33	view →
HNSC	DFS	Quartile	IV	0.699	0.483	.005	27	view →
PRAD	DFS	Median	All	0.962	0.903	.002	18	view →
MESO	OS	Median	III,IV	0.481	0.635	.021	17	view →
THCA	OS	Median	All	0.958	0.991	.013	15	view →
SKCM	DFS	Quartile	III,IV	0.784	0.389	.004	13	view →
KIRC	OS	Quartile	All	0.567	0.708	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GPRC5D–UCS (DFS)

Open the UCS breakdown →