GPRC5D

Across TCGA patient cohorts, GPRC5D mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRC5D-associated genes across cancer lineages are A-Raf_pS299, Annexin-1, and Shc_pY317. Each is linked with GPRC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5D-to-partner and partner-to-GPRC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by GPRC5D-low versus GPRC5D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5D→partner) and Y-score (partner→GPRC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.111	-2.584	.046	.011	3	1
UCEC	Annexin-1 →	+0.772	+2.341	.001	.019	3	1
UCEC	Shc_pY317 →	-0.221	-3.321	.001	.010	3	1
UCEC	Caspase-8 →	-0.271	-3.143	.020	.018	3	1
UCEC	cIAP →	+0.194	+3.331	.002	.005	3	1
UCEC	4E-BP1 →	+0.342	+2.837	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by GPRC5D expression — UCEC

Explore this box plot interactively →