GPRC5D

Across TCGA cell cohorts, GPRC5D mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPRC5D-associated genes across cancer lineages are CCL18, ACER1, and INSL5. Each is linked with GPRC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5D-to-partner and partner-to-GPRC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL18 grouped by GPRC5D-low versus GPRC5D-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5D→partner) and Y-score (partner→GPRC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCL18 →	+0.040	+4.643	<.001	.008	3	1
LARGE_INTESTINE	ACER1 →	+0.083	+3.453	.003	.009	3	1
LARGE_INTESTINE	INSL5 →	+0.286	+3.626	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CCL18 by GPRC5D expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →