GPRC5D-AS1

Across TCGA pan-cancer cohorts, GPRC5D-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GPRC5D-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GPRC5D-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GPRC5D-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and HNSC show a favorable association.

LUSC, UCS, and HNSC are the cancer types where GPRC5D-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.488	0.320	<.001	68	view →
UCS	DFS	Median	All	0.353	0.664	.001	66	view →
HNSC	OS	Tertile	IV	0.778	0.592	.001	54	view →
COAD	DFS	Median	III,IV	0.445	0.740	.003	52	view →
ACC	OS	Tertile	All	0.887	0.388	.002	41	view →
LGG	DFS	Median	All	0.678	0.794	<.001	39	view →
READ	OS	Median	II,III,IV	0.836	0.496	.002	39	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	28	view →
PRAD	DFS	Median	All	0.925	0.849	.008	18	view →
BLCA	DFS	Median	IV	0.266	0.641	<.001	15	view →
KIRC	DFS	Quartile	III,IV	0.248	0.591	.010	14	view →
LUAD	DFS	Quartile	All	0.633	0.759	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GPRC5D-AS1–LUSC (OS)

Open the LUSC breakdown →